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| c. 1489 |
| | | Leonardo da Vinci begins an unprecedented series of detailed anatomical drawings, based on corpses dissected in Rome | |
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| 1489 |
| | | Venice's annexation of Cyprus completes a useful chain of islands stretching to the eastern Mediterranean | |
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| 1490 |
| | | On the death of Matthias Corvinus, in 1490, the Habsburgs recover Vienna from the Hungarians | |
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| 1491 |
| | | Savonarola, the new prior of San Marco, is a stern critic of both the pope in Rome and the Medici in Florence | |
|  | Savonarola
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| 1491 |
| | | The king of France is among those supporting Perkin Warbeck, supposedly a prince from the Tower, in his attempt on the English throne | |
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| 1492 |
| | | A French privateer off the west coast of Ghana is the first to plunder a Portuguese vessel carrying home African gold | |
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| 1492 |
| | | The army of Ferdinand and Isabella besieges and takes the city of Granada, completing the long reconquest of Spain from the Muslims | |
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| 1492 |
| | | Torquemada persuades Ferdinand and Isabella to expel from Spain all Jews (about 160,000) who will not convert to Christianity | |
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| 1492 |
| | | Bayazid II, the Turkish sultan, makes a special point of welcoming in Istanbul the Jews expelled from Spain | |
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| 1492 |
| | | Rodrigo Borgia, elected pope as Alexander VI, already has four illegitimate children and possibly sires three more while pope | |
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